Retatrutide
Retatrutide (LY3437943)
Retatrutide is a novel triple agonist peptide that simultaneously activates GIP (glucose-dependent insulinotropic polypeptide), GLP-1 (glucagon-like peptide-1), and glucagon receptors. Research demonstrates superior metabolic outcomes compared to dual agonists, with significant effects on body weight reduction, glucose regulation, and lipid metabolism.
- ›Triple receptor agonism: GIP, GLP-1, and glucagon
- ›Significant reduction in body weight in research subjects
- ›Improved glycaemic control and insulin sensitivity
- ›Favourable effects on lipid profiles
- ›Enhanced energy expenditure via glucagon pathway